EFFICACY OF TRADITIONAL HERBAL MEDICINE IN IMPROVING TUMOR SIZE AND DISEASE CONTROL IN CANCER PATIENTS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
Nội dung chính của bài viết
Tóm tắt
Objective: To determine the efficacy and rank the superiority of various traditional herbal medicine dosage forms in improving tumor size and disease control.
Literature Search and Review: A systematic review and network meta-analysis were conducted using five databases (PubMed, Cochrane, Web of Science, Google Scholar, and CNKI) up to December 2025.
Results: Combining traditional herbal medicine significantly improved tumor size (OR = 1.77; 95% CI: 1.46 – 2.14) and disease control (OR = 1.88; 95% CI: 1.53 – 2.32) compared to the control group. Network analysis identified that traditional herbal medicine decoction combined with standard treatment was the most superior intervention for tumor size improvement (OR = 1.35; 95% CI: 1.24 – 1.48; SUCRA 79.62%). Regarding the disease control rate, decoction combined with standard treatment was the most superior intervention (OR = 1.12; 95% CI: 1.08 – 1.17; SUCRA 84.85%), while decoction alone only showed a positive trend without reaching statistical significance (OR = 1.23; 95% CI: 1.00 – 1.51; SUCRA 79.85%).
Conclusion: Traditional herbal medicine is significantly effective in improving tumor size and stabilizing the disease. Specifically, the decoction form demonstrates overwhelming superiority and should be prioritized for integration into multimodal treatment protocols for cancer patients.
Chi tiết bài viết
Từ khóa
Traditional medicine, cancer, network meta-analysis.
Tài liệu tham khảo
[2] The International Association of Cancer Registries; The World Health Organization. GLOBOCAN 2022 Vietnam. Accessed 15 January 2026. https://gco.iarc.who.int/media/globocan/factsheets/populations/704-viet-nam-fact-sheet.pdf.
[3] Ma Y, Li J, Liu L, Shen T. Efficacy and safety of oral Chinese medicine combined with chemotherapy: a systematic review and network meta-analysis. Frontiers in Pharmacology. 2025;16. DOI: 10.3389/fphar.2025.1579613.
[4] Yan H, Li Y, Guo B, Yang B, Tang D. The effect of Traditional Chinese Medicine on patients undergoing targeted therapy for primary liver cancer: a systematic review and meta-analysis. Frontiers in Oncology. 2025;15. DOI: 10.3389/fonc.2025.1674965.
[5] Yu HB, Hu JQ, Han BJ, Du YY, Chen ST, Chen X, et al. Combinatorial treatment with traditional medicinal preparations and VEGFR-tyrosine kinase inhibitors for middle-advanced primary liver cancer: A systematic review and meta-analysis. PLOS ONE. 2024;19 (11). DOI: 10.1371/journal.pone.0313443.
[6] Pan B, Lai H, Ma N, He X, Liu X, Deng X, et al. Efficacy and safety of commercial Chinese polyherbal preparation combined with oxaliplatin-based chemotherapy for gastric cancer: a systematic review and network meta-analysis. Frontiers in Pharmacology. 2025;16. DOI: 10.3389/fphar.2025.1645079.
[7] Qian R, Ge J, Fan N, Sun Z, Zhao C, Sun Y, et al. Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions. MedComm (2020). 2026;7(2). DOI: 10.1002/mco2.70585.
[8] Lin J, Wang J, Zhao K, Li Y, Zhang X, Sheng J. Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach. Annals of Medicine. 2025;57 (1). DOI: 10.1080/07853890.2025.2494671.