VALUE OF ULTRASOUND IN THE DIAGNOSIS OF PROSTATE CANCER IN PATIENTS AGED 50 YEARS AND OLDER AT MEDIC MEDICAL CENTER, 2020–2023
Main Article Content
Abstract
Objective: To evaluate the diagnostic performance of transrectal ultrasound (TRUS) features in detecting prostate cancer in men aged ≥50 years at Medic Medical Center from 2020–2023.
Methods: A retrospective cross-sectional study was conducted on 583 medical records of men aged ≥50 years who were suspected of having prostate cancer based on abnormal digital rectal examination (DRE) findings or prostate-specific antigen (PSA) levels ≥4 ng/mL at Medic Medical Center from January 2020 to April 2023.
Results: The prevalence of prostate cancer in high-risk individuals was 39.8%. TRUS features, including abnormal nodules and heterogeneous echogenicity, showed the strongest associations with prostate cancer, with sensitivities of 91.8% and 91.4%, respectively, and a specificity of 83.2% for both. The multivariate regression model demonstrated excellent diagnostic performance (AUC = 0.921). Risk stratification combining abnormal nodules, irregular prostate capsule, and increased vascularity achieved a diagnostic accuracy of 95.4%.
Conclusion: TRUS demonstrates high diagnostic value for prostate cancer in high-risk individuals through a multivariate regression model with an AUC of 0.921. These findings confirm the important role of TRUS in risk stratification and in guiding prostate biopsy indications.
Article Details
Keywords
Prostate cancer; Prostate gland; Transrectal ultrasound; TRUS.
References
2. Sighinolfi MC, Rocco B. Re: EAU Guidelines: Prostate Cancer 2019. Eur Urol. 2019; 76(6):871. doi:10.1016/j.eururo.2019.07.014
3. Merriel SWD, Funston G, Hamilton W. Prostate Cancer in Primary Care. Adv Ther. 2018; 35(9):1285-94. doi:10.1007/s12325-018-0766-1
4. Nguyễn Ngọc Hà. Đánh giá chẩn đoán và các phương pháp điều trị ngoại khoa ung thư tuyến tiền liệt: Đại học Y Dược Thành Phố Hồ Chí Minh; 2016. doi: 10.13140/RG.2.2.13369.63843.
5. Bộ Y tế. Quyết định 3130/QĐ-BYT về việc ban hành tài liệu chuyên môn "Hướng dẫn chẩn đoán và điều trị ung thư tuyến tiền liệt". Hà Nội: Bộ Y tế; 2020.
6. American Cancer Society. Prostate Cancer Early Detection, Diagnosis, and Staging American Cancer Society [Available from: https://www.cancer.org/cancer/types/prostate-cancer/detection-diagnosis-staging.html.]
7. Morgan TM PG, Partin AW, et al. Prostate Cancer Tumor Markers. Campbell-Walsh Urology. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, editors. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia: Elsevier; 2021. p. 108.
8. Grey ADR, Connor MJ, Tam J, Loch T. Can transrectal prostate ultrasound compete with multiparametric MRI in the detection of clinically significant prostate cancer? Transl Androl Urol. 2020;9(3):1492-500. doi:10.21037/tau.2020.02.26
9. Keeney E, Thom H, Turner E, Martin RM, Morley J, Sanghera S. Systematic Review of Cost-Effectiveness Models in Prostate Cancer: Exploring New Developments in Testing and Diagnosis. Value Health. 2022;25(1):133-46. doi:10.1016/j.jval.2021.07.002
10. Jang J, Kim J, Lee HJ, Chang JH. Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer. Sensors. 2021;21(4):1217. doi:10.3390/s21041217.
11. Kanagaraju V, Ashlyin PVK, Elango N, Devanand B. Role of Transrectal Ultrasound Elastography in the Diagnosis of Prostate Carcinoma. J Med Ultrasound. 2020;28(3):173-8. doi:10.4103/jmu.Jmu_108_19
12. Eyrich NW, Morgan TM, Tosoian JJ. Biomarkers for detection of clinically significant prostate cancer: contemporary clinical data and future directions. Transl Androl Urol. 2021;10(7):3091-103. doi:10.21037/tau-20-1151
13. Vapnek JM, Hricak H, Shinohara K, Popovich M, Carroll P. Staging accuracy of magnetic resonance imaging versus transrectal ultrasound in stages A and B prostatic cancer. Urol Int. 1994;53(4):191-5. doi:10.1159/000282671